Article

Benchmarking Polygenic Risk Score Model Assumptions: towards more accurate risk assessment

2022-02-18

Abstract excerpt

Polygenic risk scores represent an individual’s genetic susceptibility to a phenotype. Like with any models, statistical models commonly employed to fit polygenic risk scores and assess their accuracy contain several assumptions. The effects of these assumptions on models of polygenic risk score have not been thoroughly assessed. We assessed 26 variations of the traditional polygenic risk score model, each of whic...

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Literature Corpus work: aafc6c4b-4173-5f59-9c63-e857ac16a888
DOI: 10.1101/2022.02.18.480983

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