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Article

Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline

21 Jul 2015

Abstract excerpt

BACKGROUND: The male germline transcriptome changes dramatically during the mitosis-to-meiosis transition to activate late spermatogenesis genes and to transiently suppress genes commonly expressed in somatic lineages and spermatogenesis progenitor cells, termed somatic/progenitor genes. RESULTS: These changes reflect epigenetic regulation. Induction of late spermatogenesis genes during spermatogenesis is...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 26198001
DOI: 10.1186/s12915-015-0159-8

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