Article

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation

2020-12-16

Abstract excerpt

<h4>ABSTRACT</h4> Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases. In the present study, we performed a comparative genomic analysis of mouse SSC (Oct4-GFP+/KIT-) and differentiating progenitors (Oct4-GFP+/KIT+) isolated from yo...

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Literature Corpus work: fab83a38-586d-5b10-b8aa-61d2082aaea8
DOI: 10.1101/2020.12.15.422121

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