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Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos

14 Apr 2020

Abstract excerpt

The oocyte cytoplasm can reprogram the somatic cell nucleus into a totipotent state, but with low efficiency. The spatiotemporal chromatin organization of somatic cell nuclear transfer (SCNT) embryos remains elusive. Here, we examine higher order chromatin structures of mouse SCNT embryos using a low-input Hi-C method. We find that donor cell chromatin transforms to the metaphase state rapidly after SCNT along...

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PMID: 32286279
DOI: 10.1038/s41467-020-15607-z

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