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Article

Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells

27 Apr 2016

Abstract excerpt

Spermatogonial stem and progenitor cells (SSCs) generate adult male gametes. During in vitro expansion, these unipotent murine cells spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs). Here we investigate this conversion process through integrative transcriptomic and epigenomic analyses. We find in SSCs that promoters essential to maintenance and differentiation of embryonic stem...

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PMID: 27117588
DOI: 10.1038/ncomms11275

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