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Genome folding and zygotic genome activation in mammalian preimplantation embryos

9 Oct 2024

Abstract excerpt

The totipotent one-cell embryo, or zygote, gives rise to all germ layers and extraembryonic tissues that culminate in the development of a new organism. A zygote is produced at fertilisation by the fusion of differentiated germ cells, egg and sperm. The chromatin of parental genomes is reprogrammed and spatially reorganised in the early embryo. The 3D chromatin organisation is established de novo after...

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PMID: 39383545
DOI: 10.1016/j.gde.2024.102268

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