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The adult human testis transcriptional cell atlas

12 Oct 2018

Abstract excerpt

Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility and faithful genome propagation. Here, we performed single-cell RNA sequencing of ~6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig, myoid, Sertoli, endothelial, macrophage), and observed...

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PMID: 30315278
DOI: 10.1038/s41422-018-0099-2

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