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Article

The Landscape of Genomic and Socioeconomic Variables in Patients with Colorectal Cancer Based on Genetic Ancestry.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2026

Srinivasan Preethi, Bristow Sara L, Mendez Fernando L, Krinshpun Shifra, Jurdi Adham, Liu Minetta C, Rabinowitz Matthew, Wall Jeffrey, Bustamante Carlos D, Ioannidis Alexander G, De La Vega Francisco M, Mitchell Breeana L, Aleshin Alexey, Reiter Johannes G

Abstract excerpt

BACKGROUND: Despite differences in tumor alterations across genetic ancestries, investigations of the colorectal cancer molecular landscape have used self-reported ethnicity instead of genetic ancestry. METHODS: We used tumor and matched normal whole-exome sequencing data from 16,388 patients with stage I to IV colorectal cancer to investigate colorectal cancer's germline and somatic molecular landscape and the...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Colorectal Neoplasms

Exome Sequencing

Genetic Predisposition to Disease

Genomics

Microsatellite Instability

Socioeconomic Disparities in Health

Population Groups

Source

Open in PubMed Open full text

Identifiers

PMID: 42084482
DOI: 10.1158/1055-9965.EPI-26-0020
PMCID: PMC13530983

Genes

APC
BRAF
IMPACT
KRAS
MLH1
NTHL1
PIK3CA
PMS2
POLE
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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