Article
Alcohol consumption and molecular subtypes of colorectal cancer: pooled observational and Mendelian randomization analyses.
The American journal of clinical nutrition - 1 Jun 2026
Chalitsios Christos V, Chan Wing Ching, Markozannes Georgios, Aglago Elom K, Berndt Sonja I, Buchanan Daniel D, Campbell Peter T, Cao Yin, Dimou Niki, Drew David A, French Amy J, Gallinger Steven, Georgeson Peter, Giannakis Marios, Gruber Stephen B, Gunter Marc J, Harrison Tabitha A, Brenner Hermann, Hoffmeister Michael, Urruchúa-Rodríguez Mary-Jose, Hsu Li, Huang Wen-Yi, Hullar Meredith Aj, Huyghe Jeroen R, Jenkins Mark A, Jayasekara Harindra, Moreno Victor, Newton Christina C, Nowak Jonathan A, Obón-Santacana Mireia, Ogino Shuji, Pellatt Andrew J, Peoples Anita, Qu Conghui, Schmit Stephanie L, Steinfelder Robert S, Sun Wei, Thomas Claire E, Toland Amanda E, Trinh Quang M, Ugai Tomotaka, Um Caroline Y, Van Guelpen Bethany, Zaidi Syed H, Peters Ulrike, Phipps Amanda I, Tsilidis Konstantinos K
Abstract excerpt
BACKGROUND: Alcohol consumption is associated with colorectal cancer (CRC) risk, yet its association with distinct molecular subtypes remains unclear. Clarifying this could reveal insights into alcohol's carcinogenic mechanisms. OBJECTIVES: We examined the association between alcohol consumption and the risk of CRC subtypes defined by individual tumor markers (and marker combinations), namely microsatellite...
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