Article

Family Genetic Risk Scores for Major Psychiatric and Neurodevelopmental Diagnoses in the Norwegian Population

2026-06-21

Abstract excerpt

<p>Importance: Family history is a prominent indicator of psychiatric disorder risk and used in clinical assessment. Pearson-Aitken Family-Genetic Risk Scores (PA-FGRSs) aim to quantify genetic risk based on diagnostic history of family members and genetic relatedness. However, there is limited knowledge about how PA-FGRSs characterize psychiatric and neurodevelopmental diagnoses, clinical indicators (age of onset...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aac7b865-1160-55fd-ac7c-414b64038d1c
DOI: 10.31234/osf.io/4qtu5_v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Family Genetic Risk Scores for Major Psychiatric and Neurodevelopmental Diagnoses in the Norwegian PopulationDOI 10.31234/osf.io/4qtu5_v2Read

Family Genetic Risk Scores and the Genetic Architecture of Major Affective and Psychotic Disorders in a Swedish National Sample.Semantic proximity Read

Structure of the Genetic Risks for Psychiatric Disorders in Swedish Population-Based Registries.Semantic proximity Read

The impact of family-genetic risk scores on social functioning in individuals affected with six major psychiatric and substance use disorders in a Swedish National Sample.Semantic proximity Read

A Genetic Risk Adoption Design for Psychiatric and Substance Use Disorders.Semantic proximity Read

Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected ParentsSemantic proximity Read

PA-FGRS is a novel estimator of pedigree-based genetic liability that complements genotype-based inferences into the genetic architecture of major depressive disorderSemantic proximity Read

Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression.Semantic proximity Read

Genetic risk modeling approaches to resolve phenotypic and molecular heterogeneity in psychiatric disorders.Semantic proximity Read

Specificity of polygenic scores for psychiatric disorders beyond transdiagnostic genetic risk (p)Semantic proximity Read

The outcome of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity.Semantic proximity Read

Profiles of Genetic Risks for Psychotic Disorders.Semantic proximity Read

Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record dataSemantic proximity Read