Article

PA-FGRS is a novel estimator of pedigree-based genetic liability that complements genotype-based inferences into the genetic architecture of major depressive disorder

2023-06-29

Abstract excerpt

Large biobank samples provide an opportunity to integrate broad phenotyping, familial records, and molecular genetics data to study complex traits and diseases. We introduce Pearson-Aitken Family Genetic Risk Scores (PA-FGRS), a new method for estimating disease liability from patterns of diagnoses in extended, age-censored genealogical records. We then apply the method to study a paradigmatic complex disorder, Ma...

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Literature Corpus work: 0e642a11-2d84-5b36-adce-0e28cc0af0f8
DOI: 10.1101/2023.06.23.23291611

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