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Article

Profiles of Genetic Risks for Psychotic Disorders.

JAMA psychiatry - 1 Sept 2025

Kendler Kenneth S, Ohlsson Henrik, Sundquist Jan, Sundquist Kristina

Abstract excerpt

Importance: The etiologic interrelationship of 4 rare/controversial psychotic disorders (delusional disorder [DD], acute psychoses [AP], psychosis not otherwise specified [PNOS], and schizoaffective disorder [SAD]) is poorly understood. Objective: To assess levels of the family genetic risk score (FGRS) for schizophrenia (SZ), bipolar disorder (BD), and major depression (MD) in individuals with DD, AP, PNOS, and...

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Bipolar Disorder
Cohort Studies
Major Depressive Disorder
Psychotic Disorders
Registries

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PMID: 40632548
DOI: 10.1001/jamapsychiatry.2025.1289
PMCID: PMC12242816

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