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Article

Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents

22 Feb 2023

Abstract excerpt

Objective: Family history is an established risk factor for mental illness. The authors sought to investigate whether polygenic scores (PGSs) can complement family history to improve identification of risk for major mood and psychotic disorders. Methods: Eight cohorts were combined to create a sample of 1,884 participants ages 2–36 years, including 1,339 offspring of parents with mood or psychotic disorders, who...

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PMID: 36856707
DOI: 10.1176/appi.ajp.20220476

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