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Article

A Genetic Risk Adoption Design for Psychiatric and Substance Use Disorders.

JAMA psychiatry - 1 Jan 2026

Kendler Kenneth S, Ohlsson Henrik, Sundquist Jan, Sundquist Kristina

Abstract excerpt

Importance: Traditional adoption studies examine disorder-to-disorder parent-offspring transmission. The role of parental genetic risk in offspring disorder transmission can capture indirect genetic effects from parental genotype to parental phenotype to offspring risk. Objective: To assess the relative importance of genetic and rearing effects from paternal family genetic risk scores (FGRSs) in 3 pairs of...

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Identifiers

PMID: 41296336
DOI: 10.1001/jamapsychiatry.2025.3565
PMCID: PMC12658762

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