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Article

Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2008

Valente Pierluigi, García-Sanz Nuria, Gomis Ana, Fernández-Carvajal Asia, Fernández-Ballester Gregorio, Viana Félix, Belmonte Carlos, Ferrer-Montiel Antonio

Abstract excerpt

Transient receptor potential vanilloid receptor subtype I (TRPV1) is an ion channel gated by physical and chemical stimuli that belongs to the TRPV protein family. TRPV receptors contain a highly conserved, 6-mer segment near the channel gate, known as the TRP box, whose function remains unknown. Here, we performed an alanine scanning mutagenesis of the TRP box of TRPV1 (IWKLQR) and found that mutation of this...

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Source

Identifiers

PMID: 18559878
DOI: 10.1096/fj.08-107425

Genes

TRPV1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I.PMID 18559878Read ↗

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