Article
TRPV1.
Handbook of experimental pharmacology - 1 Jan 2014
Bevan Stuart, Quallo Talisia, Andersson David A
Abstract excerpt
TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory neurons involved in pain sensation and also at a number of other neuronal and non-neuronal sites in the mammalian body. Functionally, TRPV1 acts as a sensor for noxious heat (greater than ~42 °C). It can also be activated by some endogenous lipid-derived molecules, acidic solutions (pH < 6.5) and some pungent chemicals and food...
Topics
- Animals
- Gene Expression Regulation
- Genotype
- Humans
- Ion Channel Gating
- Membrane Potentials
- Mice
- Mice, Knockout
- Phenotype
- Phosphatidylinositols
- Phosphorylation
- Protein Conformation