The TRPV4 channel.

doi:10.1007/978-3-642-54215-2_12

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Article

The TRPV4 channel.

Handbook of experimental pharmacology - 1 Jan 2014

Garcia-Elias Anna, Mrkonjić Sanela, Jung Carole, Pardo-Pastor Carlos, Vicente Rubén, Valverde Miguel A

Abstract excerpt

The widely distributed TRPV4 cationic channel participates in the transduction of both physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and synthetic ligands) stimuli. In this chapter we will review TRPV4 expression, biophysics, structure, regulation, and interacting partners as well as physiological and pathological insights obtained in TRPV4 animal models and human genetic studies.

Topics

Animals
Gene Expression Regulation
Genetic Predisposition to Disease
Genotype
Humans
Membrane Potentials
Mice, Knockout
Protein Conformation
Signal Transduction
Structure-Activity Relationship
TRPV Cation Channels

Source

Open in PubMed

Identifiers

PMID: 24756711
DOI: 10.1007/978-3-642-54215-2_12

Genes

TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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