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Article

Contribution of the putative inner-pore region to the gating of the transient receptor potential vanilloid subtype 1 channel (TRPV1).

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jul 2007

Susankova Klara, Ettrich Rudiger, Vyklicky Ladislav, Teisinger Jan, Vlachova Viktorie

Abstract excerpt

The transient receptor potential vanilloid receptor-1 (TRPV1) is a sensory neuron-specific nonselective cation channel that is gated in response to various noxious stimuli: pungent vanilloids, low pH, noxious heat, and depolarizing voltages. By its analogy to K+ channels, the S6 inner helix domai...

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Source

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Identifiers

PMID: 17626219
DOI: 10.1523/JNEUROSCI.1956-07.2007
PMCID: PMC6672601

Genes

TRPV1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17626219-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of the putative inner-pore region to the gating of the transient receptor potential vanilloid subtype 1 channel (TRPV1).PMID 17626219Read ↗

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.Semantic proximity Read ↗

Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I.Semantic proximity Read ↗

TRPV1.Semantic proximity Read ↗

Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational data.Semantic proximity Read ↗

Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels.Semantic proximity Read ↗

Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionineSemantic proximity Read ↗

Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?Semantic proximity Read ↗

Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel.Semantic proximity Read ↗

The TRPV4 channel.Semantic proximity Read ↗

A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodentsSemantic proximity Read ↗

Ratio of hydrophobic-hydrophilic and positive-negative residues at lipid-water-interface influences surface expression and channel-gating of TRPV1Semantic proximity Read ↗

Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation.Semantic proximity Read ↗

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