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Alternative splicing expands the antiviral IFITM repertoire in Chinese rufous horseshoe bats

26 Dec 2024

Abstract excerpt

Species-specific interferon responses are shaped by the virus-host arms race. The human interferon-induced transmembrane protein (IFITM) family consists of three antiviral IFITM genes that arose by gene duplication. These genes restrict virus entry and are key players in antiviral interferon responses. The unique IFITM repertoires in different species influence their resistance to viral infections, but the role...

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PMID: 39724110
DOI: 10.1371/journal.ppat.1012763

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