Article
A viral RNA structural element alters host recognition of nonself RNA.
Science (New York, N.Y.) - 14 Feb 2014
Hyde Jennifer L, Gardner Christina L, Kimura Taishi, White James P, Liu Gai, Trobaugh Derek W, Huang Cheng, Tonelli Marco, Paessler Slobodan, Takeda Kiyoshi, Klimstra William B, Amarasinghe Gaya K, Diamond Michael S
Abstract excerpt
Although interferon (IFN) signaling induces genes that limit viral infection, many pathogenic viruses overcome this host response. As an example, 2'-O methylation of the 5' cap of viral RNA subverts mammalian antiviral responses by evading restriction of Ifit1, an IFN-stimulated gene that regulates protein synthesis. However, alphaviruses replicate efficiently in cells expressing Ifit1 even though their genomic...
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