Article

The Primate-Specific Presence of Interferon Regulatory Factor-5 Pseudogene 1

2024-07-16

Abstract excerpt

Interferon regulatory factor 5 (IRF5) is a key transcription factor regulating inflammatory cytokines and interferons, with its dysregulation linked to autoimmune and inflammatory diseases. Pseudogenes can exhibit gene regulatory functions. This study investigates the human IRF5 pseudogene 1 (IRF5P1) and its potential role in primate-specific innate immunity. We find that IRF5P1 is a chimeric processed pseudogene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4bcfbd39-68f0-57c8-bd20-b731162a06c6
DOI: 10.22541/au.172115473.33114923/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Primate-Specific Presence of Interferon Regulatory Factor-5 Pseudogene 1DOI 10.22541/au.172115473.33114923/v1Read

The Primate-Specific Presence of Interferon Regulatory Factor-5 Pseudogene 1Semantic proximity Read

IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian ordersSemantic proximity Read

Comparison of antiviral responses in two bat species reveals conserved and divergent innate immune pathwaysSemantic proximity Read

Alternative splicing expands the antiviral IFITM repertoire in Chinese horseshoe batsSemantic proximity Read

Interferon-induced protein with tetratricopeptide repeats 5 of black fruit bat (Pteropus alecto) displays a broad inhibition of RNA virusesSemantic proximity Read

IRF7 in the Australian Black Flying Fox, Pteropus alecto: Evidence for a Unique Expression Pattern and Functional ConservationSemantic proximity Read

IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA virusesSemantic proximity Read

Transduction of the human gene FAM8A1 by endogenous retrovirus during primate evolution.Semantic proximity Read

Retrotransposon-derived transcripts and their functions in immunity and diseaseSemantic proximity Read

A comparative analysis of the antiviral response in two bat species reveals conserved and divergent innate immune pathwaysSemantic proximity Read

Transposon invasion of primate genomes shaped human inflammatory enhancers and susceptibility to inflammatory diseasesSemantic proximity Read

The ancient fusogen EnvP(b)1 is expressed in human tissues and its structure informs the evolution of gammaretrovirus envelope proteinsSemantic proximity Read