Article

Prioritising Autoimmunity Risk Variants for Functional Analyses by Fine-Mapping Mutations Under Natural Selection

2021-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Pathogens imposed selective pressure on humans and shaped genetic variation in immunity genes. This can also be true for a fraction of causal variants implicated in chronic inflammatory disorders. Hence, locating adaptive mutations among candidate variants for these disorders can be a promising way to prioritize and decipher their functional response to microbial stimuli and contribution to path...

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Literature Corpus work: aa8626e6-bae2-5887-929b-a5cef41632a4
DOI: 10.1101/2021.11.01.466789

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