Article

Ancient DNA reveals that natural selection has upregulated the immune system over the last 10,000 years

2026-04-14

Abstract excerpt

The specific mechanisms through which human biology and disease susceptibility evolved with major shifts in West Eurasian environments and societies over the last 10,000 years( 1 )—particularly rising infectious burden( 2 )—remain poorly characterized, despite ancient DNA studies( 3-6 ) identifying hundreds of candidate loci under positive selection( 6 ). Here, we identify specific immune diseases/traits, gene...

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Literature Corpus work: d0da8af4-64be-5d57-b7c2-bee75a138829
DOI: 10.64898/2026.04.14.718409

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