Genetic variants regulating immune cell levels in health and disease.

doi:10.1016/j.cell.2013.08.041

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Article

Genetic variants regulating immune cell levels in health and disease.

Cell - 26 Sept 2013

Orrù Valeria, Steri Maristella, Sole Gabriella, Sidore Carlo, Virdis Francesca, Dei Mariano, Lai Sandra, Zoledziewska Magdalena, Busonero Fabio, Mulas Antonella, Floris Matteo, Mentzen Wieslawa I, Urru Silvana A M, Olla Stefania, Marongiu Michele, Piras Maria G, Lobina Monia, Maschio Andrea, Pitzalis Maristella, Urru Maria F, Marcelli Marco, Cusano Roberto, Deidda Francesca, Serra Valentina, Oppo Manuela, Pilu Rosella, Reinier Frederic, Berutti Riccardo, Pireddu Luca, Zara Ilenia, Porcu Eleonora, Kwong Alan, Brennan Christine, Tarrier Brendan, Lyons Robert, Kang Hyun M, Uzzau Sergio, Atzeni Rossano, Valentini Maria, Firinu Davide, Leoni Lidia, Rotta Gianluca, Naitza Silvia, Angius Andrea, Congia Mauro, Whalen Michael B, Jones Chris M, Schlessinger David, Abecasis Gonçalo R, Fiorillo Edoardo, Sanna Serena, Cucca Francesco

Abstract excerpt

The complex network of specialized cells and molecules in the immune system has evolved to defend against pathogens, but inadvertent immune system attacks on "self" result in autoimmune disease. Both genetic regulation of immune cell levels and their relationships with autoimmunity are largely un...

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PMID: 24074872
DOI: 10.1016/j.cell.2013.08.041
PMCID: PMC5541764

Genes

ATXN2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24074872-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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