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Article

Common risk alleles for inflammatory diseases are targets of recent positive selection.

American journal of human genetics - 4 Apr 2013

Raj Towfique, Kuchroo Manik, Replogle Joseph M, Raychaudhuri Soumya, Stranger Barbara E, De Jager Philip L

Abstract excerpt

Genome-wide association studies (GWASs) have identified hundreds of loci harboring genetic variation influencing inflammatory-disease susceptibility in humans. It has been hypothesized that present day inflammatory diseases may have arisen, in part, due to pleiotropic effects of host resistance to pathogens over the course of human history, with significant selective pressures acting to increase host resistance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23522783
DOI: 10.1016/j.ajhg.2013.03.001
PMCID: PMC3617371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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