Article

Cellular response to small molecules that selectively stall protein synthesis by the ribosome

2018-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Identifying small molecules that inhibit protein synthesis by selectively stalling the ribosome constitutes a new strategy for therapeutic development. Compounds that inhibit the translation of PCSK9, a major regulator of low-density lipoprotein cholesterol, have been identified that reduce LDL cholesterol in preclinical models and that affect the translation of only a few off-target proteins. A...

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Literature Corpus work: 697245fb-f66c-5f22-bc14-ba16dbc51e42
DOI: 10.1101/461624

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