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Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation

8 Sept 2022

Abstract excerpt

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET) and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling (Ribo-lite) with messenger RNA sequencing to co-profile the translatome and transcriptome in human oocytes and early embryos. Comparison with mouse counterparts identified widespread differentially translated gene functioning in...

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PMID: 36074823
DOI: 10.1126/science.abo7923

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