Article

CDCP1 Deletion Protects Against Pressure Overload-Induced Cardiac Dysfunction and Fibrosis in Mice

2026-05-08

Abstract excerpt

<title>Abstract</title> <p> Human genomic studies link reduced CUB domain-containing protein 1 (CDCP1) expression with myocardial recovery in heart failure. While CDCP1 regulates cardiac fibroblast proliferation in vitro, it’s in vivo role in cardiac fibrosis remains unclear. Using a <italic>Cdcp1</italic> -knockout (KO) angiotensin II/phenylephrine mouse model, we show that Cdcp1 deletion reduces echocardiogr...

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Literature Corpus work: aa5ac3c7-1d29-57d1-b4df-e9eb40f29de0
DOI: 10.21203/rs.3.rs-9236741/v1

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