Article
Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes.
The European respiratory journal - 1 Jul 2022
Du Mingxia, Jiang Haibin, Liu Hongxian, Zhao Xin, Zhou Yu, Zhou Fang, Piao Chunmei, Xu Guoqiang, Ma Feng, Wang Jianan, Perros Frederic, Morrell Nicholas W, Gu Hong, Yang Jun
Abstract excerpt
BACKGROUND: Mutations in bone morphogenetic protein type II receptor (BMPR2) have been found in patients with congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH). Our study aimed to clarify whether deficient BMPR2 signalling acts through downstream effectors, inhibitors of DNA-binding proteins (IDs) during heart development to contribute to the progress of PAH in CHD patients. METHODS:...
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