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Analysis of myocardial cellular gene expression during pressure overload reveals matrix based functional intercellular communication

23 Feb 2022

Abstract excerpt

To identify cellular mechanisms responsible for pressure overload triggered heart failure, we isolated cardiomyocytes, endothelial cells, and fibroblasts as most abundant cell types from mouse hearts in the subacute and chronic stages after transverse aortic constriction (TAC) and performed RNA-sequencing. We detected highly cell-type specific transcriptional responses with characteristic time courses and active...

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PMID: 35281736
DOI: 10.1016/j.isci.2022.103965

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