Article

HIV-1 Protease Evolvability is Affected by Synonymous Nucleotide Recoding

2018-05-07

Abstract excerpt

<h4>ABSTRACT</h4> One unexplored aspect of HIV-1 genetic architecture is how codon choice influences population diversity and evolvability. Here we compared the development of HIV-1 resistance to protease inhibitors (PIs) between wild-type (WT) virus and a synthetic virus (MAX) carrying a codon-pair re-engineered protease sequence including 38 (13%) synonymous mutations. WT and MAX viruses showed indistinguishabl...

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Literature Corpus work: aa49c42c-a2e9-5be0-8663-9b86d6035e15
DOI: 10.1101/315366

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