Article

A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells

2018-09-21

Abstract excerpt

During craniofacial development, cranial neural crest (CNC) cells migrate into the developing face and form bone through intramembranous ossification. Loss of JAGGED1 (JAG1) signaling in the CNC cells is associated with maxillary hypoplasia or maxillary bone deficiency (MBD) in mice and recapitulates the MBD seen in humans with Alagille syndrome. JAGGED1, a membrane-bound NOTCH ligand, is required for normal crani...

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Literature Corpus work: aa35d034-aa49-5cc4-85e9-69e3c1d77850
DOI: 10.1101/421305

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