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Article

Ectopic Hedgehog Signaling Causes Cleft Palate and Defective Osteogenesis.

Journal of dental research - 1 Dec 2018

Hammond N L, Brookes K J, Dixon M J

Abstract excerpt

Cleft palate is a common birth defect that frequently occurs in human congenital malformations caused by mutations in components of the Sonic Hedgehog (S HH) signaling cascade. Shh is expressed in dynamic, spatiotemporal domains within epithelial rugae and plays a key role in driving epithelial-mesenchymal interactions that are central to development of the secondary palate. However, the gene regulatory networks...

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Bone Morphogenetic Proteins
Cleft Palate
Hedgehog Proteins
Mandible
Neural Crest
Osteogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Smoothened Receptor

Wnt Signaling Pathway

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PMID: 29975848
DOI: 10.1177/0022034518785336
PMCID: PMC6262265

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