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Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in <i>Runx2</i> <i>+</i>/<i>−</i> mice

11 Oct 2010

Abstract excerpt

Mesenchymal stem cell commitment to an osteoprogenitor lineage requires the activity of Runx2, a molecule implicated in the etiopathology of multiple congenital craniofacial anomalies. Through promoter analyses, we have recently identified a new direct transcriptional target of Runx2, Nell-1, a craniosynostosis (CS)-associated molecule with potent osteogenic properties. This study investigated the mechanistic and...

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PMID: 20939017
DOI: 10.1002/jbmr.267

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Related research

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Research trail→

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Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in <i>Runx2</i> <i>+</i>/<i>−</i> micePMID 20939017Read ↗

Cumulative inactivation of Nell-1 in Wnt1 expressing cell lineages results in craniofacial skeletal hypoplasia and postnatal hydrocephalus.Semantic proximity Read ↗

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defectsSemantic proximity Read ↗

Craniosynostosis in transgenic mice overexpressing Nell-1.Semantic proximity Read ↗

NELL-1, an Osteoinductive Factor, Is a Direct Transcriptional Target of OsterixSemantic proximity Read ↗

Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation.Semantic proximity Read ↗

Functional impact of pathogenic Runt domain mutations in <i>Runx2</i> on skeletal and dental development in cleidocranial dysplasiaSemantic proximity Read ↗

Different Roles of Runx2 During Early Neural Crest–Derived Bone and Tooth DevelopmentSemantic proximity Read ↗

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal developmentSemantic proximity Read ↗

Functional impact of pathogenic mutations in the runt homology domain of mouse Runx2 on skeletal and dental phenotypes in cleidocranial dysplasia.Semantic proximity Read ↗

Runx2 Regulates Endochondral Ossification Through Control of Chondrocyte Proliferation and DifferentiationSemantic proximity Read ↗

Runx2 Protein Expression Utilizes the Runx2 P1 Promoter to Establish Osteoprogenitor Cell Number for Normal Bone FormationSemantic proximity Read ↗

Runx2, a multifunctional transcription factor in skeletal development.Semantic proximity Read ↗

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