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Article

Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear

23 May 2017

Abstract excerpt

Whereas Jagged1-Notch2 signaling is known to pattern the sensorineural components of the inner ear, its role in middle ear development has been less clear. We previously reported a role for Jagged-Notch signaling in shaping skeletal elements derived from the first two pharyngeal arches of zebrafish. Here we show a conserved requirement for Jagged1-Notch2 signaling in patterning the stapes and incus middle ear...

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PMID: 28566723
DOI: 10.1038/s41598-017-02574-7

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