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Article

Canonical Notch signaling is required for bone morphogenetic protein-mediated human osteoblast differentiation

14 Jun 2020

Abstract excerpt

Osteoblast differentiation of bone marrow-derived human mesenchymal stem cells (hMSC) can be induced by stimulation with canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMPs). However, it remains elusive how these two pathways lead to the same phenotypic outcome. Since Runx2 is regarded as a master regulator of osteoblastic differentiation, we targeted Runx2 with siRNA in hMSC. This abrogated...

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PMID: 32535942
DOI: 10.1002/stem.3245

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