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Article

Hedgehog Activation Regulates Human Osteoblastogenesis.

Stem cell reports - 14 Jul 2020

Onodera Shoko, Saito Akiko, Hojo Hironori, Nakamura Takashi, Zujur Denise, Watanabe Katsuhito, Morita Nana, Hasegawa Daigo, Masaki Hideki, Nakauchi Hiromitsu, Nomura Takeshi, Shibahara Takahiko, Yamaguchi Akira, Chung Ung-Il, Azuma Toshifumi, Ohba Shinsuke

Abstract excerpt

Two genetic diseases, Gorlin syndrome and McCune-Albright syndrome (MAS), show completely opposite symptoms in terms of bone mineral density and hedgehog (Hh) activity. In this study, we utilized human induced pluripotent stem cell (iPSC)-based models of the two diseases to understand the roles of Hh signaling in osteogenesis. Gorlin syndrome-derived iPSCs showed increased osteoblastogenesis and mineralization...

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Identifiers

PMID: 32531191
DOI: 10.1016/j.stemcr.2020.05.008
PMCID: PMC7363748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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