Article

<i>kcna1a</i> mutant zebrafish as a model of episodic ataxia type 1 and epilepsy

2022-09-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> KCNA1 mutations are associated with a rare neurological movement disorder known as episodic ataxia type 1 (EA1), with epilepsy as a common comorbidity. Current medications only provide partial relief to ataxia and/or seizures, making new drugs needed. Here, we investigate the utility of zebrafish kcna1a −/− as a model of EA1 with epilepsy by characterizing its phenotype and...

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Literature Corpus work: a9e58c9d-1ae7-5e13-84a4-b11ee2435168
DOI: 10.1101/2022.09.28.509973

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