Zebrafish as a Model System for the Study of Severe CaV2.1 (α1A) Channelopathies

Abstract excerpt

P/Q-type CaV2.1 channel regulate neurotransmitter release at neuromuscular junctions and many central synapses. CACNA1A encodes the pore-containing 1A subunit of CaV2.1 channels. In humans, de novo CACNA1A mutations result in a wide spectrum of neurological, neuromuscular and movement disorders, such as familial hemiplegic migraine type 1, episodic ataxia type 2, as well as a more recently discovered class of...

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