Article

Seizure-like behavior and hyperactivity in <i>napb</i> knockout zebrafish as a model for autism and epilepsy

2025-03-24

Abstract excerpt

We identified N -ethylmaleimide-sensitive factor attachment protein beta ( NAPB ) as a potential risk gene for autism and epilepsy. Notably, Qatari monozygotic triplets with loss of function mutations in NAPB exhibit early onset epileptic encephalopathy and varying degrees of autism. In this study, we generated NAPB zebrafish model using CRISPR-Cas9-sgRNAs technology for gene editing of the two orthologs napba...

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Literature Corpus work: 8199f812-9c3d-51f2-bbbf-0ecc5116605f
DOI: 10.1101/2025.03.24.644881

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