Article

Phenotypic analysis of catastrophic childhood epilepsy genes: The Epilepsy Zebrafish Project

2021-02-12

Abstract excerpt

Genetic engineering techniques have contributed to the now widespread use of zebrafish to investigate gene function, but zebrafish-based human disease studies, and particularly for neurological disorders, are limited. Here we used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing catastrophic childhood epilepsies. We evaluated larval phenotypes using electrophysiological, behavioral, neuro...

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Literature Corpus work: 0bf3b8ad-1086-542b-8337-fd46c7dcdc6a
DOI: 10.1101/2021.02.11.430844

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