Article

EGR3 Deletion Rescues Developmental and Epileptic Encephalopathy in <i>Kcna1</i> -null Mice

2025-06-11

Abstract excerpt

KCNA1 encodes the α-subunit of the voltage-gated potassium channel K V 1.1. Mutations in K V 1.1’s pore domain result in developmental and epileptic encephalopathy (DEE), where early life seizures and a culprit lesion synergistically disrupt neurodevelopmental trajectories, resulting in intellectual disability that often presents with disturbances in sleep, sociability and sensory processing. Abnormalities in th...

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Literature Corpus work: e515dfef-4ac8-55f2-89f3-1ced5d16efe9
DOI: 10.1101/2025.06.07.658422

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