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Article

Epilepsy, Behavioral Abnormalities, and Physiological Comorbidities in Syntaxin-Binding Protein 1 (STXBP1) Mutant Zebrafish.

PloS one - 1 Jan 2016

Grone Brian P, Marchese Maria, Hamling Kyla R, Kumar Maneesh G, Krasniak Christopher S, Sicca Federico, Santorelli Filippo M, Patel Manisha, Baraban Scott C

Abstract excerpt

Mutations in the synaptic machinery gene syntaxin-binding protein 1, STXBP1 (also known as MUNC18-1), are linked to childhood epilepsies and other neurodevelopmental disorders. Zebrafish STXBP1 homologs (stxbp1a and stxbp1b) have highly conserved sequence and are prominently expressed in the larval zebrafish brain. To understand the functions of stxbp1a and stxbp1b, we generated loss-of-function mutations using...

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Identifiers

PMID: 26963117
DOI: 10.1371/journal.pone.0151148
PMCID: PMC4786103

Genes

STXBP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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