Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia.

Genes & development - 1 Aug 2023

Sigvardsson Mikael

Abstract excerpt

Rapid advances in genomics have opened unprecedented possibilities to explore the mutational landscapes in malignant diseases, such as B-cell acute lymphoblastic leukemia (B-ALL). This disease is manifested as a severe defect in the production of normal blood cells due to the uncontrolled expansion of transformed B-lymphocyte progenitors in the bone marrow. Even though classical genetics identified translocations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Gene Expression Regulation
Share to Leukemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Transcription Factors

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 37673459
DOI: 10.1101/gad.349879.122
PMCID: PMC10546977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia.PMID 37673459Read ↗

Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemiaSemantic proximity Read ↗

B-lineage transcription factors and cooperating gene lesions required for leukemia development.Semantic proximity Read ↗

PAX5 alterations in B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Cell Fate Decisions: The Role of Transcription Factors in Early B-cell Development and LeukemiaSemantic proximity Read ↗

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.Semantic proximity Read ↗

Genes and childhood leukemia.Semantic proximity Read ↗

Signaling Proteins and Transcription Factors in Normal and Malignant Early B Cell DevelopmentSemantic proximity Read ↗

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemiaSemantic proximity Read ↗

Genetic defects in hematopoietic transcription factors and predisposition to acute lymphoblastic leukemiaSemantic proximity Read ↗

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 casesSemantic proximity Read ↗

PAX5 fusion genes in acute lymphoblastic leukemia: A literature review.Semantic proximity Read ↗

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.