Article
Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.
The Journal of experimental medicine - 6 Jun 2011
Heltemes-Harris Lynn M, Willette Mark J L, Ramsey Laura B, Qiu Yi Hua, Neeley E Shannon, Zhang Nianxiang, Thomas Deborah A, Koeuth Thearith, Baechler Emily C, Kornblau Steven M, Farrar Michael A
Abstract excerpt
As STAT5 is critical for the differentiation, proliferation, and survival of progenitor B cells, this transcription factor may play a role in acute lymphoblastic leukemia (ALL). Here, we show increased expression of activated signal transducer and activator of transcription 5 (STAT5), which is correlated with poor prognosis, in ALL patient cells. Mutations in EBF1 and PAX5, genes critical for B cell development...
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