Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B-lineage transcription factors and cooperating gene lesions required for leukemia development.

Leukemia - 1 Mar 2013

Tijchon E, Havinga J, van Leeuwen F N, Scheijen B

Abstract excerpt

Differentiation of hematopoietic stem cells into B lymphocytes requires the concerted action of specific transcription factors, such as RUNX1, IKZF1, E2A, EBF1 and PAX5. As key determinants of normal B-cell development, B-lineage transcription factors are frequently deregulated in hematological malignancies, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and affected by either chromosomal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neoplasm Proteins
Share to B-Lymphocytes
Share to ABL1 gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to IKZF1 gene

Share to PAX5 gene

Share to Leukemia

Share to Mutation

Share to Transcription Factors

Source

Identifiers

PMID: 23047478
DOI: 10.1038/leu.2012.293

Genes

ABL1
BTG1
CRLF2
EBF1
IKZF1
JAK2
PAX5
RUNX1
TBL1XR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B-lineage transcription factors and cooperating gene lesions required for leukemia development.PMID 23047478Read ↗

Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemiaSemantic proximity Read ↗

Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia.Semantic proximity Read ↗

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.Semantic proximity Read ↗

Signaling Proteins and Transcription Factors in Normal and Malignant Early B Cell DevelopmentSemantic proximity Read ↗

Cell Fate Decisions: The Role of Transcription Factors in Early B-cell Development and LeukemiaSemantic proximity Read ↗

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemiaSemantic proximity Read ↗

Genes and childhood leukemia.Semantic proximity Read ↗

PAX5 alterations in B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Pathogenesis and prognostication in acute lymphoblastic leukemiaSemantic proximity Read ↗

Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathwaysSemantic proximity Read ↗

Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of <i>ETV6-RUNX1</i> negative B precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.