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mTOR inhibition <i>via</i> Rapamycin treatment partially reverts the deficit in energy metabolism caused by FH loss in RPE cells

2021-10-30

Abstract excerpt

Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including ageing, genetics and lifestyle choices. The combination of these factors leads to oxidative stress, inflammation and metabolic failure in the retinal pigment epithelium (RPE) with subsequent degeneration of photoreceptors in the retina. The alternative complement pathway is tightly...

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Literature Corpus work
a9d18698-447b-52cf-a9e5-8f2fdc076819
DOI
10.1101/2021.10.29.466270
Open publication

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mTOR inhibition <i>via</i> Rapamycin treatment partially reverts the deficit in energy metabolism caused by FH loss in RPE cellsDOI 10.1101/2021.10.29.466270
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