The Complement Factor H (Y402H) risk polymorphism for age-related macular degeneration affects metabolism and response to oxidative stress in the retinal pigment epithelium.

doi:10.1016/j.freeradbiomed.2024.10.307

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The Complement Factor H (Y402H) risk polymorphism for age-related macular degeneration affects metabolism and response to oxidative stress in the retinal pigment epithelium.

Free radical biology & medicine - 20 Nov 2024

Shang Peng, Ambrosino Helena, Hoang Johnson, Geng Zhaohui, Zhu Xiaoyu, Shen Shichen, Eminhizer Mark, Hong Elise, Zhang Ming, Qu Jun, Du Jianhai, Montezuma Sandra R, Dutton James R, Ferrington Deborah A

Abstract excerpt

Age-related macular degeneration (AMD), the leading cause of central vision loss in the elderly, involves death of the retinal pigment epithelium (RPE) and light-sensing photoreceptors. This multifactorial disease includes contributions from both genetic and environmental risk factors. The current study examined the effect of the Y402H polymorphism of Complement Factor H (CFH, rs1061170) and cigarette smoke,...

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PMID: 39491736
DOI: 10.1016/j.freeradbiomed.2024.10.307
PMCID: PMC11662989

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