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Article

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells

2020-01-08

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. About 50% of AMD patients present polymorphisms in the Complement Factor H ( CFH ) gene, coding for Factor H protein (FH). AMD-associated CFH risk variants, Y402H in particular, impair FH function leading to complement overactivation. In AMD, retinal homeostasis is compromised due to dysfunction of retinal pigment...

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Literature Corpus work
341b1cbb-b2c7-5475-b6a0-392b0ac365bd
DOI
10.1101/2020.01.08.898551
Open publication

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Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cellsDOI 10.1101/2020.01.08.898551
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