Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa

11 Aug 2016

Abstract excerpt

Retinitis pigmentosa (RP) is an incurable neurodegenerative condition featuring photoreceptor death that leads to blindness. Currently, there is no approved therapeutic for photoreceptor degenerative conditions like RP and atrophic age-related macular degeneration (AMD). Although there are promising results in human gene therapy, RP is a genetically diverse disorder, such that gene-specific therapies would be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27516389
DOI: 10.1093/hmg/ddw256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosaPMID 27516389Read ↗

Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa.Semantic proximity Read ↗

Precision metabolome reprogramming for imprecision therapeutics in retinitis pigmentosaSemantic proximity Read ↗

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and RepairSemantic proximity Read ↗

Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases.Semantic proximity Read ↗

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa miceSemantic proximity Read ↗

PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa.Semantic proximity Read ↗

Autophagy Dysfunction and Oxidative Stress, Two Related Mechanisms Implicated in Retinitis PigmentosaSemantic proximity Read ↗

CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosaSemantic proximity Read ↗

Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.Semantic proximity Read ↗

Photoreceptor metabolic reprogramming: current understanding and therapeutic implicationsSemantic proximity Read ↗

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.Semantic proximity Read ↗

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.